| Dr Philipp Getto one year's stay will be devoted to the
development and analysis of mathematical models,
algorithms and computer software related to
carcinogenesis and cancer population growth using
partial differential, integro-differential and
integral equations. In particular using his experience
in the area of nonlinear structured population models
Philipp will be responsible for the design of models
for the evolution of the density function for
distribution of differentiation of cells leading to
the process of carcinogenesis including feedback
mechanisms in this process. Analysis of these models
using both analytical and simulation tools may improve
the understanding of the process of cancer formation
and eventually aid prevention in oncology. Moreover
cooperating with biologists and clinicians from the
Institute of Oncology, branch Gliwice, Philipp will be
able to verify the model using data from in vitro
experiments on cell lines. The other class of models
that are to be analyzed is related to tumor invasion
and initiation and to the evolution of metastasis at
the molecular level. Both types of models are located
in the main task of activity of the Polish Team. The
Polish Team co-ordinates Task 1 of the project, i.e.
Mathematical modeling and computer simulation at the
sub-cellular scale and cellular scale.
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